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沙眼衣原体是一种严格细胞内寄生的革兰氏阴性细菌。它容易导致生殖道黏膜上皮细胞的感染, 从而导致生殖道的急慢性炎性病变,如慢性盆腔炎、不孕症、以及宫外孕等。造成机体损伤的主要机理是来自于机体的免疫反应。以往大量的实验室资料表明,沙眼衣原体热休克蛋白-60(CHSP-60)在机体的免疫机制中起到非常关键的作用:TH1／TH2细胞因子平衡点的漂移对于机体损伤亦发生重要的作用。CHSP-60和TH1／TH2 细胞因子形成一个调节网络,共同参与生殖道衣原体感染的免疫病理损伤。
Chlamydia trachomatis is a strictly intracellular parasitic Gram-negative bacteria. It easily lead to genital tract mucosal epithelial cell infection, resulting in genital tract acute and chronic inflammatory lesions, such as chronic pelvic inflammatory disease, infertility, and ectopic pregnancy. The main mechanism of damage caused by the body’s immune response. In the past a large number of laboratory data show that Chlamydia trachomatis heat shock protein-60 (CHSP-60) in the body’s immune mechanism plays a key role: TH1 / TH2 cytokine balance point drift for the body injury also play an important role . CHSP-60 and TH1 / TH2 cytokines form a regulatory network that together participate in the immunopathological damage of genital Chlamydia infections.