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30年前,在非洲,镰状细胞贫血(SCA)患者很少活到成年,多数患者在5岁前死于贫血、感染或心力衰竭。现在,求医的 SCA 患者10%是成年人。纯合子 SCA 患儿往往身体发育不良,并且可有性腺和骨骼发育延迟。严重的是,这些患者的生育力有降低的倾向.迄今,这些报告仅限于女性患者.作者报告一组男性 SCA 患者生育力的研究结果。男性患者40例,年龄17岁以上(平均20.56岁),均处于疾病稳定期。患者的血红蛋白类型用醋酸纤维电泳测定(pH 为8.9)。病史收集包括:年龄,婚姻
Thirty years ago in Africa, patients with sickle cell anemia (SCA) rarely lived adulthood, and most died of anemia, infection or heart failure before age 5. Currently, 10% of SCA patients seeking treatment are adults. Homozygous SCA children often have poor body growth and may have delayed gonadal and skeletal development. Seriously, these patients have a reduced fertility and to date, these reports have been limited to female patients and the authors report on the results of a study of fertility in a group of men with SCA. Forty male patients were over 17 years of age (average 20.56 years) and were in stable disease. The patient’s hemoglobin type was determined by cellulose acetate electrophoresis (pH 8.9). Medical history includes: age, marriage