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目的:探讨视黄醇结合蛋白4(RBP4)与妊娠期高血压疾病的相关性。方法:选取2009年1月~2012年12月在该院住院分娩的单胎妊娠妇女89例,其中43例妊娠期高血压疾病妇女为A组,46例正常妊娠妇女为B组。测定两组RBP4、肾功能和血脂水平,并分析RBP4与血压、肾功能及血脂的相关性和妊娠期高血压疾病的影响因素。结果:A组总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白(LDL)、尿酸(UA)及RBP4水平均高于B组(P<0.05)。RBP4水平与收缩压(SBP)、舒张压(DBP)、TC、TG、LDL及UA均呈正相关,与高密度酯蛋白(HDL)呈负相关。妊娠期高血压疾病的影响因素是UA、TG和RBP4。结论:RBP4是妊娠期高血压疾病的独立危险因素,说明RBP4在妊娠高血压疾病的发病过程中起一定作用。
Objective: To investigate the relationship between retinol binding protein 4 (RBP4) and gestational hypertension. Methods: A total of 89 singleton pregnant women were hospitalized in our hospital from January 2009 to December 2012. Of them, 43 women with pregnancy-induced hypertension were Group A, and 46 women with normal pregnancy were Group B. The levels of RBP4, renal function and blood lipid levels in both groups were determined. The correlation between RBP4 and blood pressure, renal function and blood lipids and the influencing factors of gestational hypertension were analyzed. Results: The levels of total cholesterol (TC), triglyceride (TG), low density lipoprotein (LDL), uric acid (UA) and RBP4 in group A were higher than those in group B (P <0.05). RBP4 levels were positively correlated with SBP, DBP, TC, TG, LDL and UA, but negatively correlated with HDL. The influencing factors of hypertensive disorders during pregnancy are UA, TG and RBP4. Conclusion: RBP4 is an independent risk factor for gestational hypertension, indicating that RBP4 play a role in the pathogenesis of hypertensive disorders of pregnancy.