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目的初步探讨外周血中淋巴细胞和单核细胞绝对值的比值(Lymphocyte to Monocyte Ratio,LMR)与三阴性乳腺癌预后的相关性,及与总生存时间的关系。方法回顾性分析2010年11月1日至2015年12月31日辽宁省肿瘤医院110例行乳腺癌根治术三阴性乳腺癌患者临床病理资料,根据患者术前外周静脉血LMR分为低LMR组(LMR<4.24,50例)和高LMR组(LMR≥4.24,60例);采用Kaplan-Meier生存分析法绘制生存曲线,比较两组患者的5年生存率,分析两组患者临床病理因素与总生存时间的关系。结果 LMR与三阴性乳腺癌之间具有相关性,低LMR组5年生存率为30.00%,高LMR组5年生存率为66.67%;两组相比较,5年生存率差异具有统计学意义(x~2=25.475,P<0.05);经Log Rank统计学分析,两组总生存时间相比较,差异具有统计学意义(x~2=6.932,P<0.05)。结论在三阴性乳腺癌患者中,术前外周血LMR可作为一个独立的危险因素,影响三阴性乳腺癌患者的预后。
Objective To investigate the relationship between Lymphocyte to Monocyte Ratio (LMR) in peripheral blood and the prognosis of triple negative breast cancer and its relationship with the overall survival time. Methods The clinical and pathological data of 110 patients with triple-negative breast cancer undergoing radical mastectomy from November 1, 2010 to December 31, 2015 in Liaoning Cancer Hospital were retrospectively analyzed. According to the LMR of preoperative peripheral venous blood, (LMR <4.24, 50 cases) and high LMR group (LMR≥4.24, 60 cases). Survival curve was drawn by Kaplan-Meier survival analysis. The 5-year survival rate was compared between the two groups. The clinical and pathological factors The relationship between total survival time. Results There was a correlation between LMR and triple-negative breast cancer. The 5-year survival rate was 30.00% in low LMR group and 66.67% in high LMR group. The difference of 5-year survival rate between the two groups was statistically significant There was significant difference between the two groups in total survival time (x ~ 2 = 6.932, P <0.05) by Log Rank statistical analysis. Conclusion In patients with triple-negative breast cancer, preoperative peripheral blood LMR may serve as an independent risk factor affecting the prognosis of triple-negative breast cancer patients.