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用放射免疫测定法测定脑创伤大鼠血浆及海马匀浆中内皮素、降钙素基因相关肽含量，观察纳络酮对内皮素、降钙素基因相关肽水平及海马神经元坏死的影响．结果，脑创伤后血浆及海马中内皮素含量明显升高，降钙素基因相关肽含量明显下降，海马坏死神经元计数增加；经纳络酮治疗后血浆和海马内内皮素含量较创伤组明显下降，降钙素基因相关肽含量明显升高，海马神经元计数减少．认为脑创伤后海马缺血、神经元坏死与内皮素含量升高，降钙素基因相关肽含量下降有关；纳络酮可通过降低内皮素，提高降钙素基因相关肽水平而发挥对海马神经元的保护作用
The content of endothelin and calcitonin gene-related peptide in plasma and hippocampus homogenate of rats with traumatic brain injury were measured by radioimmunoassay. The effects of naloxone on the level of endothelin, calcitonin gene related peptide and hippocampal neuron necrosis were observed. Results After traumatic brain injury, the levels of endothelin in plasma and hippocampus were significantly increased, the content of calcitonin gene-related peptide was significantly decreased, and the counts of neurons in hippocampus were increased. The content of endothelin in plasma and hippocampus after naloxone treatment was significantly higher than that in traumatic group Decreased, calcitonin gene-related peptide content was significantly increased, decreased hippocampal neuron count. It is believed that hippocampal ischemia and neuron necrosis after traumatic brain injury are related to the increase of endothelin and the decrease of calcitonin gene-related peptide. Naloxone exerts its effect on hippocampal neurons by decreasing endothelin and increasing calcitonin gene-related peptide Yuan’s protection