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促肾上腺皮质激素(ACTH)与肾上腺皮质细胞受体结合,激活腺苷酸环化酶产生环磷酸腺苷(cAMP),后者能激活酶系统使胆固醇转化为孕烯酮,再由肾上腺皮质细胞合成肾上腺皮质激素,其中主要的是氢化可的松,小部分是男性激素,对产生醛固酮的作用不强,一般不受ACTH控制。下丘脑分泌ACTH释放激素控制脑下垂体释放ACTH.下丘脑又受环境应激和血液中氢化可的松
Adrenocorticotropic hormone (ACTH) binds to adrenocortical receptors and activates adenylate cyclase to produce cyclic adenosine monophosphate (cAMP), which activates the enzyme system to convert cholesterol to pregnenolone, which in turn is activated by adrenocortical cells Synthesis of adrenocorticotropic hormone, which is mainly hydrocortisone, a small part of the male hormone, the role of the production of aldosterone is not strong, generally not controlled by ACTH. Hypothalamic secretion of ACTH-releasing hormone controls the pituitary gland to release ACTH .Hypothalamus is also affected by environmental stress and hydrocortisone in the blood