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研制抗口腔厌氧菌药替硝唑口腔粘贴片。方法:用替硝唑加适宜的辅料压制成片,测定其溶出度和唾液中的药物浓度。结果:口腔粘贴片可迅速达到口腔厌氧菌的抑菌浓度,并能维持有效的药物浓度6h以上。结论:替硝唑口腔粘贴片是一种值得开发的药物制剂。
Development of anti-oral anaerobic tinidazole oral sticking tablets. Methods: Tinidazole with appropriate excipients pressed into tablets, measured the dissolution and drug concentration in saliva. Results: The oral adhesive patch can quickly reach the oral bacteriostatic concentration of anaerobic bacteria, and can maintain effective drug concentration more than 6h. Conclusion: Tinidazole oral sticking tablets is a worthwhile development of pharmaceutical preparations.