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慢性肝病患者(CLD)常伴有血小板减少症,其原因常归于脾功能的亢进。最近动力学研究显示CLD患者的一个显著特点是血小板被脾脏隔离,是否由于脾脏功能抑或由于血小板内在损伤,尤其是膜损伤从而导致血小板放清除,目前尚不清楚。 许多文献报道,CLD患者的血小板相关IgG(PAIgG)有所增高。为了评估PAIgG在CLD患者血小板减少中的作用及血小板减少的机制,作者采用特异性糖蛋白免疫分析方法检测了36例不同病因CLD患者的PAIgG或循环抗血小板抗体对血小板糖蛋白GP Ⅱb/Ⅲa或GPⅠb/Ⅸ复合物的反应。 36例CLD患者,男16例,女20例,平均年龄53
Chronic liver disease (CLD) is often accompanied by thrombocytopenia, the reason is often due to hypersplenism. Recent kinetic studies have shown that a striking feature of patients with CLD is the isolation of platelets by the spleen, whether the spleen is functional, or due to intrinsic platelet damage, especially membrane damage leading to platelet clearance, which is unclear. Many articles report an increase in platelet-associated IgG (PAIgG) in patients with CLD. To assess the role of PAIgG in thrombocytopenia and the mechanism of thrombocytopenia in patients with CLD, the authors used a specific glycoprotein immunoassay to detect the effect of PAIgG or circulating anti-platelet antibodies on platelet glycoprotein GP IIb / IIIa or GPIb / IX complex reaction. 36 cases of CLD patients, 16 males and 20 females, with an average age of 53