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口腔癌约占全身癌的3％,其中最多见的是口腔鳞癌。口腔鳞癌与多种因素有关,如烟、酒、射线、病毒和慢性刺激物等。尽管日益增多的证据表明病毒,尤其是人类乳头瘤病毒(HPV)与口腔鳞癌的发生有关,但病毒的作用仍不清楚。迄今已发现75种不同的HPV基因型,其中16种存在于口腔病损中。虽然许多研究证实口腔中存在HPV且HPV的两个早期基因(E6,E7)产物具有潜在致癌性和永生化能力,但由于研究样本、
Oral cancer accounts for about 3% of systemic cancer, the most common of which is oral squamous cell carcinoma. Oral squamous cell carcinoma and a variety of factors, such as tobacco, alcohol, radiation, viruses and chronic irritants. Despite the growing evidence that viruses, especially human papillomavirus (HPV), are associated with the development of oral squamous cell carcinoma, the role of the virus remains unclear. So far, 75 different HPV genotypes have been found, of which 16 are present in oral lesions. Although many studies confirm the presence of HPV in the oral cavity and the potential for oncogenic and immortalization of two early genes (E6, E7) products of HPV, due to the study sample,