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目的:探讨蓝光联合茵栀黄颗粒口服治疗新生儿重症高胆红素血症的疗效。方法:选择住院足月新生儿120例为研究对象,按黄疸水平将其分为对照组(12.9 mg/dL≤总胆红素TBL<20 mg/dL,60例)及实验组(TBL≥20 mg/dL,n=60),均采取光疗联合茵栀黄口服退黄治疗;每隔24 h对血中的胆红素水平进行测定,直到达到目标安全胆红素水平(TBL≤20 mg/dL)。并于入院48 h内及黄疸治疗结束1个月后对两组患儿分别进行头颅MRI检查;于黄疸治疗结束1个月后进行BAEP检查。结果:本治疗方法在两组患儿中均可以很快降低总胆红素水平,且各时间点具有统计学差异(P<0.05),但在退黄时间上没有统计学差异(P>0.05),且均可以治疗神经系统损害的程度,其有效率不存在显著性差异(P>0.05)。结论:蓝光联合茵栀黄颗粒治疗新生儿重症高胆红素血症具有良好的退黄疗效并可以改善神经系统的损害,与治疗轻症组比较,具有非劣效性。
Objective: To investigate the curative effect of Blu-ray combined with Yinzhihuang granule in oral treatment of neonatal severe hyperbilirubinemia. Methods: A total of 120 newborn infants in hospital were selected as study subjects and divided into control group (12.9 mg / dL≤ TBL <20 mg / dL, 60 cases) and experimental group (TBL≥20 mg / dL, n = 60). All patients were given phototherapy combined with Yinhuang Huang oral Huang treatment. The level of bilirubin in blood was measured every 24 h until the target safe bilirubin level was reached (TBL≤20 mg / dL). And within 48 h after admission and 1 month after the end of jaundice treatment, cranial MRI was performed on both groups respectively. BAEP was performed one month after the end of jaundice treatment. Results: The total bilirubin level can be quickly reduced in both groups with statistical significance (P <0.05) at all time points, but there was no significant difference between the two groups (P> 0.05 ), And can treat the degree of nervous system damage, the effective rate there is no significant difference (P> 0.05). CONCLUSION: The combination of blue light and Yinzhihuang granule in the treatment of neonatal severe hyperbilirubinaemia has a good antipyretic effect and can improve the nervous system damage. Compared with the treatment of mild disease group, noninferiority is achieved.