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目的：探讨牛磺酸对离体家兔视网膜组织脂质过氧化反应、超氧化物歧化酶（ｓｕｐｅｒｏｘｉｄｅｄｉｓｍｕｔａｓｅ，ＳＯＤ）及谷胱甘肽过氧化物酶（ｇｌｕｔａｔｈｉｏｎｅｐｅｒｏｘｉｄａｓｅ，ＧＳＨ－Ｐｘ）活性的影响。方法：将家兔眼球视杯置于４组（对照组、模型组、牛磺酸组、β－胡萝卜素组）培养液中，５％ＣＯ２，３７℃温育。分别于２４小时和４８小时后测定视网膜组织中ＳＯＤ、ＧＳＨ－Ｐｘ、蛋白及丙二醛（ｍａｌｏｎｄｉａｌｄｅｈｙｄｅ，ＭＤＡ）。结果：牛磺酸与β－胡萝卜素一样可以抑制视网膜组织内脂质过氧化反应，减少ＭＤＡ生成；对ＳＯＤ保护作用不确定，对ＧＳＨ－Ｐｘ无保护作用。结论：牛磺酸可抑制视网膜组织脂质过氧化反应，其机制可能与对ＳＯＤ、ＧＳＨ－Ｐｘ活性的影响无关。
Objective: To investigate the effects of taurine on the activity of lipid peroxidation, superoxide dismutase (SOD) and glutathioneperoxidase (GSH-Px) in isolated rabbit retina. Methods: Rabbit eye cup was placed in culture medium of 4 groups (control group, model group, taurine group and β-carotene group) and incubated at 37 ℃ with 5% CO2. Retinal tissue SOD, GSH-Px, protein and malondialdehyde (MDA) were measured 24 hours and 48 hours later. Results: Taurine, like β-carotene, could inhibit the lipid peroxidation in retinal tissue and decrease the production of MDA. Its protective effect on SOD was uncertain and had no protective effect on GSH-Px. CONCLUSION: Taurine can inhibit the lipid peroxidation in the retinal tissue. The mechanism may be related to the activity of SOD and GSH-Px.