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二年来笔者在门诊用小剂量东茛菪碱治疗哮喘持续状态5例,其中男3例,女2例。年龄最小16岁,最大56岁。病程最短3年,最长20年以上。剂量最小0.6毫克,最大1.8毫克。5例哮喘均在半小时～1小时后平息,疗效满意。体会:东莨菪碱治疗哮喘,可能与下列作用途径有关;1.调节植物神经功能,疏通肺均微循环;2.阻断 M 型和 a 型受体,抑制 c-GMP释放,使 c-AMP 相应增高,从而松弛支气管平滑肌;3.对大脑皮质具有显著镇静作用及呼吸中枢兴奋作用。本文5例哮喘持续状态,经用常规解痉止喘
In the past two years, I used small doses of scopolamine in outpatient treatment of asthma in 5 cases, including 3 males and 2 females. Youngest 16 years old, maximum 56 years old. The shortest duration of 3 years, up to 20 years or more. The smallest dose of 0.6 mg, the largest 1.8 mg. 5 cases of asthma subsided in half an hour ~ 1 hour, with satisfactory results. Experience: Scopolamine treatment of asthma may be related to the following ways of action: 1. The regulation of autonomic function, clear the lungs are microcirculation; 2. Blocking of M and a receptor, inhibition of c-GMP release, so that c-AMP increased accordingly , Thereby relaxing bronchial smooth muscle; 3. Significant sedation of the cerebral cortex and respiratory center excitement. In this paper, 5 cases of asthma persist state, with conventional antispasmodic anti-asthma