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Objectives The purpose of this study was to determine the relative risk of deep vein thrombosis(DVT)during preg-nancy and puerperium in a setting that was not influenced by diagnostic suspicion and referra l bias.Study design Three hundred ninetythree consecut ive females with suspi-cion of a first episode of venous thro mbosis were referred in the same way to diagnostic centers.Medical history was obtained before objective testing f or deep vein thrombosis.Results Seventy -six of the 393females were diagnosed as having deep vein thrombosis;the oth ers were used as control subjects.The odds ratios fo r pregnancy,cesarean section,and puerperium after adjustment for age,center,family history,and calendar timewe re,respectively,5.7(95%CI 2.5-12.9),4.0(95%CI 1.3-12.6),and2.9(95%CI 1.2-6.9).Conclusion In this case -con-trol study,in which patients and con trol patients were subject to the same referral and diag nostic procedures,we found similar risk estimates for pre gnancy and puerperium as in previous studies.Our findings show that previous studies were less affected by diagnostic suspicion and re-ferral bias than presumed.
Objectives The purpose of this study was to determine the relative risk of deep vein thrombosis (DVT) during preg-nancy and puerperium in a setting that was not affected by diagnostic suspicion and referra bias. Studiy Three Three Ninetythree consecut ive females with suspi -cion of a first episode of venous thro mbosis were referred in the same way to diagnostic centers. Medical history was obtained before objective testing f or deep vein thrombosis. Results Seventy -six of the 393 females were diagnosed as having deep vein thrombosis; the oth ers were used as control subjects. The odds ratios fo r pregnancy, cesarean section, and puerperium after adjustment for age, center, family history, and calendar timewere, respectively, 5.7 (95% CI 2.5-12.9), 4.0 CI 1.3-12.6), and 2.9 (95% CI 1.2-6.9) .Conclusion In this case -con-trol study, in which patients and con trol patients were subject to the same referral and diag nostic procedures, we found similar risk estimates for pre gnancy and puerperium as in previous studies. Our findings show that previous studies were less affected by diagnostic suspicion and re-ferral bias than presumed.