自1988年日本学者Yanagisaws等首先从猪主动脉内皮细胞分离出内皮素[1]以来，近十年的研究发现内皮素（ET）是一种具有多种生物功能的多肽，与人体多种疾病关系密切。我们观察了48例慢性肾小球肾炎患者血浆ET含量与血尿素氮（BUN）、肌酐（Cr）的关系，现报告如下。资料和方法1 Since the Japanese scholar Yanagisaws et al first isolated endothelin from porcine aortic endothelial cells in 1988 [1], nearly ten years of research have found that endothelin (ET) is a kind of polypeptide with many biological functions, Close relationship. We observed 48 patients with chronic glomerulonephritis plasma ET content and blood urea nitrogen (BUN), creatinine (Cr), the report is as follows. Data and methods 1