基因治疗可能是预防神经元变性的最有用的方法。腺病毒载体、腺相关病毒载体及逆转录病毒载体等,作为将神经营养因子基因转移到以非神经元细胞为靶细胞的的主要方法,具有潜在的区域特异性、持续性、耐受性的特点,并能稳定表达神经营养因子蛋白,可逆转衰老等多种因素导致的胆碱能神经元变性,引起功能的恢复。 Gene therapy may be the most useful method of preventing neuronal degeneration. Adenovirus vectors, adeno-associated virus vectors, retroviral vectors, and the like, have potential regio-specific, sustained, and tolerogenic as the primary method of transferring neurotrophic factor genes to non-neuronal cells as target cells Characteristics, and stable expression of neurotrophic factor protein, can reverse aging and other factors lead to degeneration of cholinergic neurons, causing functional recovery.