多环芳烃化合物广泛地存在于大气、水、土壤和植物中,是主要的环境污染物之一。流行病学调查和动物实验研究,发现致癌性的多环芳烃化合物与肺癌发生有密切关系。对哺乳类动物代谢的研究证明,哺乳动物的肝和肺是代谢外源性化学物质的重要器官,这种代谢经体内混合功能氧化酶(MFO)作用,将外源性化学物质一方面灭活,另一方面又代谢激活生成环氧化物或终末致癌物质。由呼吸道进入体内的多环芳烃化合物首先与肺上皮细胞直接接触,在混合功能氧化 PAHs are widely found in the atmosphere, water, soil and plants, and are one of the major environmental pollutants. Epidemiological investigation and animal experiments show that carcinogenic PAHs are closely related to the occurrence of lung cancer. Studies of mammalian metabolism have demonstrated that mammalian liver and lungs are important organs for the metabolism of exogenous chemicals that, through in vivo mixed-function oxidase (MFO), inactivate exogenous chemicals on the one hand On the other hand, it is metabolically activated to form epoxide or terminal carcinogen. PAHs entering the body from the respiratory tract are first directly contacted with lung epithelial cells and mixed with functionalized