目的:探究糖皮质激素药理作用及在临床用药安全性?方法:研究对象为86例肾病综合征患者，均为我院2020年1月至2021年1月收治，采用电脑随机法将其分为干预组(糖皮质激素+常规西药治疗)和对照组(常规西药治疗)，各43例，比较两组临床疗效及不良反应发生率?结果:干预组临床治疗有效率(93.02%)显著高于对照组(76.74%)，组间差异有统计学意义(P<0.05);干预组患者不良反应发生率(69.78%)明显高于对照组(9.30%)，差异有统计学意义(P<0.05)?结论:糖皮质激素临床应用广泛，治疗效果“,”Objective:To explore the pharmacological effects of glucocorticoids and the safety of clinical medications. Methods:The subjects of the study were 86 patients with nephrotic syndrome， all of whom were admitted to our hospital from January 2020 to January 2021. They were divided into an intervention group (glucocorticoids + conventional western medicine treatment) and a control group (Conventional Western medicine treatment)， 43 cases in each group， the clinical efficacy and the incidence of adverse reactions between the two groups were compared. Results:The effective rate of clinical treatment in the intervention group (93.02%) was significantly higher than that of the control group (76.74%)， and the difference between the groups was statistically significant (P<0.05); the incidence of adverse reactions in the intervention group (69.78%) was significantly higher than that in the control group Group (9.30%)， the difference was statistically significant (P<0.05). Conclusion:Glucocorticoids are widely used in clinical applications and have significant therapeutic effects. They have the effects of anti-inflammatory， regulating blood lipids and blood sugar. However， patients have more adverse reactions after taking them， such as central obesity， elevated blood pressure and blood sugar， skin rashes， infections， etc.， so clinically The medication should be used with caution， taking into full consideration the patient\'s tolerance， and achieving reasonable and safe medication.