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目的观察P27蛋白在胃癌中的表达,探讨P27蛋白表达与胃癌发生发展、临床病理特征之间的关系。方法采用SP免疫组化方法检测P27蛋白在60例胃癌组织、17例异型增生和15例正常胃粘膜中的表达。结果P27蛋白在正常胃粘膜、异型增生和胃癌中的阳性表达率分别为100%,58.82%,38.33%,表达差别均有显著性(P<0.05);早期胃癌与异型增生组相比阳性率无明显差异性(P>0.05);进展期胃癌P27蛋白表达显著低于早期胃癌(31.82%VS 56.25%,P<0.05);且随着淋巴结转移、分化程度降低、浸润深度加深、器官转移等,P27蛋白表达阳性率逐渐降低(P<0.05)。结论P27蛋白表达在胃癌发生发展中进行性下调,其可作为判断胃癌病理生物学行为的客观指标。
Objective To observe the expression of P27 protein in gastric carcinoma and to explore the relationship between the expression of P27 protein and the development and clinicopathological features of gastric carcinoma. Methods SP immunohistochemical method was used to detect the expression of P27 protein in 60 cases of gastric carcinoma, 17 cases of dysplasia and 15 cases of normal gastric mucosa. Results The positive rates of P27 protein in normal gastric mucosa, dysplasia and gastric cancer were 100%, 58.82% and 38.33%, respectively (P <0.05). The positive rates of P27 protein in early gastric cancer compared with dysplasia (P <0.05). The expression of P27 protein in advanced gastric cancer was significantly lower than that in early stage gastric cancer (31.82% VS 56.25%, P <0.05), and with the lymph node metastasis, the differentiation degree was decreased, the depth of invasion was deeper, , The positive rate of P27 protein decreased (P <0.05). Conclusion The expression of P27 protein is down-regulated in the development of gastric cancer, which can be used as an objective index to judge the pathological and biological behavior of gastric cancer.