为准确地从体外溶出试验结果预测药物的体内行为,溶出试验中所用的介质应尽可能地与体内胃肠道环境相似。为此设计了生物相关的溶出介质,即在介质中加入含不同脂肪量的牛奶、卵白蛋白、明胶、酪蛋白、谷蛋白、碳水化合物或氨基酸,用其评价食物成分对酮康唑固有溶出速率的影响。结果显示, In order to accurately predict the in vivo behavior of the drug from the in vitro dissolution test, the medium used for the dissolution test should be as similar as possible to the in vivo gastrointestinal environment. To this end, biologically relevant dissolution media are designed such that milk, ovalbumin, gelatin, casein, gluten, carbohydrates or amino acids with different amounts of fat are added to the medium to evaluate the inherent dissolution rate of the food component to ketoconazole Impact. The results show,