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2,4-二氯苯酚是新的β受体阻滞剂B24/76的代谢产物,曾在人、狗、鼠和小猪的尿中测到过,它亦是农药2,4-二氯苯酚乙酸的代谢物,氯苯酚还是一类重要的环境污染物。本文介绍一种新方法,同时测定大鼠或人血清与尿中2,4-二氯苯酚和B24/76,以估计连续使用B24/76后2,4-二氯苯酚可能产生的毒性。仪器与色谱条件HPLC仪,LC—XPS泵,Rheodyne70—10型进样器,SeparonSGX18玻璃柱(5μm,15cm×3.2mm,id)
2,4-Dichlorophenol is a metabolite of the new beta-blocker B24 / 76, which has been measured in the urine of humans, dogs, rats and piglets and is also a pesticide 2,4-dichloro- Phenol acetic acid metabolites, chlorophenols or a class of important environmental pollutants. This article describes a new method for the simultaneous determination of 2,4-dichlorophenol and B24 / 76 in rat or human serum and urine to assess the potential toxicity of 2,4-dichlorophenol after continuous use of B24 / 76. Instrument and Chromatographic Conditions HPLC instrument, LC-XPS pump, Rheodyne Model 70-10 injector, Separon SGX18 glass column (5 μm, 15 cm × 3.2 mm, id)