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目的探究克罗米芬对卵巢储备功能减退患者进行促排卵治疗的有效性。方法随机抽取80例本院接收的卵巢储备功能减退患者,并按照不同的治疗方法分为对照组和观察组,每组各40例患者。给予对照组患者人绝经期促性腺激素/人绒毛促性腺激素(HMG/HCG)进行治疗,观察组则给予克罗米芬进行治疗。比较两组患者的排卵率、妊娠率以及不良反应发生率。结果两组患者的排卵率分别为50.00%(对照组)、87.50%(观察组);妊娠率分别为5.00%(对照组)、30.00%(观察组),差异有统计学意义(P<0.05)。两组患者的不良反应发生率分别为10.00%(对照组),7.50%(观察组),差异无统计学意义(P>0.05)。结论克罗米芬对改善卵巢储备功能减退患者的妊娠率、排卵率具有显著疗效,值得广泛应用。
Objective To investigate the efficacy of clomiphene for ovulation induction in patients with ovarian reserve deficit. Methods Totally 80 cases of ovarian reserve dysfunction received in our hospital were randomly divided into control group and observation group with 40 cases in each group according to different treatment methods. Patients in the control group were treated with menopausal gonadotrophin / human chorionic gonadotropin (HMG / HCG), while those in the observation group received clomiphene. The ovulation rate, pregnancy rate and incidence of adverse reactions in the two groups were compared. Results The ovulation rates of the two groups were 50.00% (control group) and 87.50% (observation group) respectively. The pregnancy rates were 5.00% (control group) and 30.00% (observation group) respectively, the difference was statistically significant (P <0.05 ). Adverse reactions in both groups were 10.00% (control group) and 7.50% (observation group), respectively, with no significant difference (P> 0.05). Conclusions Clomiphene has a significant effect on improving the pregnancy rate and ovulation rate in patients with hypofunctional ovarian reserve. It is worth to be widely used.