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目的比较甘精胰岛素和预混胰岛素两种方案的治疗效果和低血糖发生情况。以便寻找出更加适合老年糖尿病患者的方便有效的治疗方案。方法选取曾在我科住院患者50例,年龄大于70岁,男性26例,女性24例,甘精组(25例)根据患者的生活习惯按每天早上7点或晚上9点皮下注射一次甘精胰岛素,预混组(25例)根据血糖值进行调整胰岛素用量,早餐及晚餐前30分钟皮下注射诺和灵30R,根据两组患者餐后血糖的情况,加用阿卡波糖和/或二甲双胍,出院后随访3个月观察血糖控制和低血糖情况。结果两组患者应用胰岛素治疗后,低血糖发生次数,甘精组明显低于预混组(P<0.05)差异具有统计学意义。甘精组的胰岛素用量明显少于预混组(P<0.001)差异具有统计学意义。结论单用口服降糖药不能使血糖达标时,加用甘精胰岛素或预混胰岛素治疗,均能明显降低血糖,甘精胰岛素与预混胰岛素相比用量少且低血糖的发生率低,更适合老年患者。
Objective To compare the therapeutic effects of hypoglycemia and premixed insulin with hypoglycaemia. In order to find a more convenient and effective treatment for elderly diabetic patients. Methods Fifty patients who were hospitalized in our department were selected, aged above 70 years, 26 males and 24 females, and 25 patients in Gan Gan group were injected subcutaneously with Gan Gan Jing at 7:00 am or 9:00 pm according to the patients’ lifestyle. Insulin, pre-mixed group (25 cases) according to the amount of insulin to adjust the amount of insulin, 30 minutes before breakfast and dinner subcutaneous injection of Novolin 30R, according to two groups of patients with postprandial blood glucose, add acarbose and / or metformin , Followed by 3 months after discharge to observe the blood sugar control and hypoglycemia. Results After insulin treatment, the frequency of hypoglycemia and the level of glycine in the two groups were significantly lower than those in the premixed group (P <0.05). Glycerine group was significantly less than the amount of insulin pre-mixed group (P <0.001) difference was statistically significant. Conclusions Single oral hypoglycemic agents can not make blood glucose compliance, with insulin glargine or premixed insulin treatment, can significantly lower blood glucose, insulin glargine and pre-mixed insulin dosage less and the incidence of low blood sugar is low, More suitable for elderly patients.