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目的评价2型糖尿病和糖耐量异常对原发性高血压患者左室收缩功能的影响。方法原发性高血压患者92例,年龄(52±13)岁,其中女性24例,接受常规超声和组织多普勒成像应变率(SR)检查,其中合并2型糖尿病患者25例,合并糖耐量异常27例。结果合并2型糖尿病或糖耐量异常患者的常规超声心动图左室收缩功能指标与单纯原发性高血压患者无显著差异(P>0·05)。合并2型糖尿病患者各节段的SR均比合并糖耐量异常(前侧壁心尖部P<0·05,其余均为P<0·01)和单纯原发性高血压患者(室间隔心尖部P<0·01,其余均为P<0·001)小,合并糖耐量异常患者部分节段的SR(室间隔基底部、前侧壁基底部和心尖部,P<0·05)较单纯性高血压患者小。SR与性别、年龄、E/A比值、IV1RT和LVMI等均无相关性(P>0·05)。结论在常规方法显示左室收缩功能正常的原发性高血压患者中,超声成像应变技术提示合并糖尿病及糖耐量异常的高血压患者左室收缩功能较单纯高血压患者有一定程度降低。
Objective To evaluate the effect of type 2 diabetes mellitus and impaired glucose tolerance on left ventricular systolic function in patients with essential hypertension. Methods Totally 92 patients with essential hypertension (aged 52 ± 13), including 24 females, underwent routine ultrasonography and tissue Doppler imaging strain rate (SR) examination. Among 25 patients with type 2 diabetes mellitus, Abnormal tolerance in 27 cases. Results Conventional echocardiography in patients with type 2 diabetes mellitus or impaired glucose tolerance showed no significant differences in left ventricular systolic function between those with simple essential hypertension (P> 0.05). The SR of each segment of patients with type 2 diabetes mellitus was significantly higher than those of patients with simplex hypertension (P <0.05, P <0.01) P <0.01, the rest were P <0.001), SR (basal and anterior basal and basal apoplexy, P <0.05) in some segments of patients with impaired glucose tolerance was significantly lower than that of simple Hypertensive patients are small. There was no correlation between SR and sex, age, E / A ratio, IV1RT and LVMI (P> 0.05). Conclusion In patients with essential hypertension with normal left ventricular systolic function in conventional methods, ultrasound imaging and strain technique suggest that left ventricular systolic function in hypertensive patients with diabetes mellitus and impaired glucose tolerance may be reduced to a certain extent.