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目的探讨茵栀黄颗粒治疗新生儿病理性黄疸的临床疗效。方法选取2013年1月—2015年1月湘潭市妇幼保健院收治的新生儿病理性黄疸患儿130例,按随机数字表法分为观察组与对照组,各65例。对照组患儿予以蓝光治疗,观察组患儿在对照组基础上加用茵栀黄颗粒治疗。观察两组患儿临床疗效、治疗前、治疗3d血清胆红素(BIL)水平、平均退黄时间。结果观察组患儿总有效率高于对照组,差异有统计学意义(P<0.05);治疗前两组患儿血清BIL水平比较,差异无统计学意义(P>0.05),治疗3d观察组患儿血清BIL水平低于对照组,差异有统计学意义(P<0.05);观察组患儿平均退黄时间短于对照组,差异有统计学意义(P<0.05)。结论茵栀黄颗粒治疗新生儿病理性黄疸的临床疗效显著,可降低血清BIL水平,缩短退黄时间。
Objective To investigate the clinical efficacy of Yinzhihuang granule in treating neonatal pathological jaundice. Methods From January 2013 to January 2015, 130 cases of neonatal pathological jaundice admitted to Xiangtan MCH were randomly divided into observation group and control group with 65 cases in each group. Children in the control group were treated with blue light. Children in the observation group were treated with Yinzhihuang granules on the basis of the control group. The clinical curative effect was observed in two groups. Before treatment, the level of serum bilirubin (BIL) and the mean time to revert to yellow were observed. Results The total effective rate of observation group was higher than that of control group, the difference was statistically significant (P <0.05). There was no significant difference in serum BIL levels between the two groups before treatment (P> 0.05) The serum level of BIL in children was lower than that in the control group (P <0.05). The mean time to retirement in the observation group was shorter than that in the control group (P <0.05). Conclusion Yinzhihuang Granules is effective in treating neonatal pathological jaundice, which can reduce serum BIL level and shorten the time of rehmannia.