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干扰素治疗丙型病毒性肝炎的效果已被公认,但治愈率各家报道不一。为了解干扰素治疗效果与HCV基因型和HCV RNA滴度的关系,本文作者将接受干扰素治疗的53例日本慢性丙型肝炎病人作了基因分型和HCV RNA滴度检测。 60例病人(男46例,女14例)均由组织学和血清学检查证实为慢性丙型肝炎病人,而无乙型肝炎、酒精性肝炎、自身免疫性肝炎及药物性肝炎的证据。其中30例(甲组)每次肌注干扰素3MU,开始2周每日1次,以后每周3次,共用26周;另30例(乙组)
The efficacy of interferon in the treatment of hepatitis C virus has been recognized, but the cure rates vary widely. To understand the relationship between the effect of interferon therapy and HCV genotype and HCV RNA titer, the authors performed genotyping and HCV RNA titer tests in 53 Japanese chronic hepatitis C patients treated with interferon. Sixty-six patients (46 males and 14 females) were confirmed by histological and serological tests as patients with chronic hepatitis C without any evidence of hepatitis B, alcoholic hepatitis, autoimmune hepatitis and drug-induced hepatitis. 30 cases (group A) each intramuscular injection of interferon 3MU, started once a week for 2 weeks, then 3 times a week for 26 weeks; the other 30 cases (group B)