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本文以醋酸铅作为受试物,将受孕大鼠随机分为20mg/kg、40mg/kg、60mg/kg3个剂量组和对照组;将受孕小鼠随机分为试验组(60mg/kg)、阴性对照组和甲基硫氧嘧啶组(25mg/只/次)。从大鼠受孕第13天,小鼠受孕第10天腹腔注射染毒,隔两天1次,共3次。甲基硫氧嘧啶组灌胃,共3次。实验结果表明,试验组胎鼠血清和羊水T_3、T_4水平及仔鼠平均体重明显下降,试验组和甲基硫氧嘧啶组仔鼠多种神经行为发育明显延迟于对照组仔鼠。说明,铅对胎鼠甲状腺功能、仔鼠体重增长以及多种神经行为发育有明显的抑制作用。铅对胎鼠甲状腺功能的影响可能是仔鼠神经行为和智力发育迟缓的重要原因。
In this article, lead acetate was used as the test substance, and the pregnant rats were randomly divided into 3 dose groups of 20 mg/kg, 40 mg/kg, and 60 mg/kg, and the control group; the pregnant mice were randomly divided into test groups (60 mg/kg) and negative controls. Group and methyl thiouracil group (25 mg/only/time). From the 13th day of pregnancy in the rat, the mice were intraperitoneally injected on the 10th day of conception, once every two days for a total of 3 times. The methylthiouracil group was given orally for 3 times. The experimental results showed that the levels of T_3 and T_4 in fetal mice serum and amniotic fluid and the average body weight of pups were significantly decreased in the experimental group. The neurobehavioral development of the experimental group and the methyl thiouracil group was significantly delayed in the control group. Explained that lead has a significant inhibitory effect on fetal thyroid function, fetal rat weight gain and a variety of neurobehavioral development. The effect of lead on fetal thyroid function may be an important cause of neurobehavioral and mental retardation in young rats.