本文对β-烷胺基酮衍生物的HPLC参数logk′与体外抑癌活性间的关系进行研究,并建立了logk′与体外抑癌活性的定量相关模型。研究结果表明,logk′与体外抑癌活性明显相关,在一定范围内,体外抑癌活性随着logk′的增大而增强。从而为进一步寻找抑癌活性更高的化合物指明了方向。 In this paper, the relationship between logk ’, an HPLC parameter of β-alkanaminone derivatives, and the anti-tumor activity in vitro was studied, and a quantitative correlation model between logk’ and anti-tumor activity in vitro was established. The results showed that logk ’was significantly correlated with anti-tumor activity in vitro. In a certain range, the anti-tumor activity in vitro increased with the increase of logk’. Thus indicating the direction for further searching for a compound having higher tumor suppressor activity.