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目的探讨血清雌二醇(E_2)及卵泡刺激素(FSH)水平与更年期不适临床症状的相关性。方法选取2014年6月-2016年6月该院妇科收治的129例具有更年期不适症状的妇女为病例组,按照血清E_2水平将其分为低E_2组(56例)和高E_2组(73例),按照血清FSH水平将其分为低FSH组(49例)和高FSH组(80例)。于同期随机选取80例无明显更年期症状的妇女为对照组,采用更年期生活质量评分量表(MRS)对患者的临床症状进行评分,分析血清E_2和FSH水平与患者临床症状的关系。结果病例组血清E_2水平低于对照组,FSH水平高于对照组,差异有统计学意义(P<0.05)。低E_2组各项临床症状(潮热出汗、心脏症状、睡眠障碍、抑郁障碍等)评分及总分均高于高E_2组,低FSH组各项临床症状(潮热出汗、心脏症状、睡眠障碍、抑郁障碍等)评分及总分均低于高FSH组,差异均有统计学意义(P<0.05)。Spearman积矩相关分析显示,血清E_2水平与更年期症状评分呈负相关(r=-0.752,P<0.05),血清FSH水平与更年期症状评分呈正相关(r=0.718,P<0.05)。结论更年期不适妇女的血清E_2水平降低、FSH水平升高,二者可作为评估更年期不适临床症状发生的重要指标。
Objective To investigate the correlation between serum estradiol (E2) and follicle stimulating hormone (FSH) levels and clinical symptoms of menopausal discomfort. Methods From June 2014 to June 2016, 129 women with menopausal symptoms admitted to our hospital from June 2014 to June 2016 were selected as the case group and divided into low E_2 group (56 cases) and high E_2 group (73 cases ) Were divided into low FSH group (n = 49) and high FSH group (n = 80) according to serum FSH level. In the same period, 80 women with no obvious menopause symptoms were randomly selected as the control group. Clinical symptoms were evaluated by menopause quality of life scale (MRS), and the relationship between serum E_2 and FSH levels and clinical symptoms were analyzed. Results The level of serum E_2 in the case group was lower than that in the control group, and the level of FSH was higher than that in the control group (P <0.05). The scores and total scores of clinical symptoms (hot flashes, cardiac symptoms, sleep disorders, depression disorders, etc.) in low E_2 group were higher than those in high E_2 group and low FSH group (hot flashes, cardiac symptoms, Sleep disorders, depression, etc.) score and total score were lower than the high FSH group, the difference was statistically significant (P <0.05). Spearman product moment correlation analysis showed that there was a negative correlation between serum E2 level and menopausal symptom score (r = -0.752, P <0.05). Serum FSH level was positively correlated with menopausal symptom score (r = 0.718, P <0.05). Conclusions Women with menopausal discomfort have lower serum E2 levels and higher FSH levels, both of which may be used as an important index to evaluate clinical symptoms of menopausal discomfort.