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目的:研究银蒺胶囊对冠脉结扎所致急性心肌缺血大鼠的保护作用。方法:选择心电图正常的SD大鼠90只,随机分成6组(正常对照组,模型组,阿司匹林组,银蒺低剂量组、中剂量组、高剂量组)。除正常组外,均行冠状动脉结扎,制成心肌梗死模型。药物组给予相应药物,对照组、模型组给予等量生理盐水,灌胃14 d,末次灌胃1 h后,接心电图机并以监测和记录标准Ⅱ导联心电图;心电图描记结束后,经腹主动脉采血,对血清中心肌酶谱、血脂相关指标进行检测。结果:与模型组比较,银蒺胶囊各剂量组、阿司匹林组血清肌酸激酶、肌酸激酶同工酶、α-羟基丁酸脱氢酶值均显著降低(P≤0.05);与模型组比较,在30 s、5 min、30 min、60 min时心电图ST段抬高的幅度较低,差异有统计学意义(P≤0.05);与模型组比较,银蒺胶囊高剂量组、中剂量组、阿司匹林组血清三酰甘油含量均显著降低(P≤0.05);银蒺胶囊各剂量组及阿司匹林组高密度脂蛋白的水平显著升高(P≤0.05)。结论:银蒺胶囊能有效改善心肌缺血,并能够调节血脂,从而保护心肌。
Objective: To study the protective effect of Yin Tiao capsule on acute myocardial ischemia induced by coronary artery occlusion in rats. Methods: Ninety Sprague-Dawley rats with normal electrocardiogram were selected and randomly divided into 6 groups (normal control group, model group, aspirin group, low-dose group, middle-dose group and high-dose group). In addition to the normal group, coronary artery ligation, made of myocardial infarction model. The rats in the drug group were given the corresponding drugs, the control group and the model group were given the same amount of saline, gavage 14 days, the last gavage 1 h, then connected to the ECG machine to monitor and record the standard Ⅱ lead ECG; electrocardiogram after the end of the abdomen Aortic blood, serum myocardial enzymes, serum lipid-related indicators were detected. Results: Compared with the model group, the serum creatine kinase, creatine kinase and α-hydroxybutyrate dehydrogenase levels in each dose group and aspirin group were significantly decreased (P≤0.05); compared with the model group , The amplitude of ST segment elevation in ECG was lower at 30 s, 5 min, 30 min and 60 min (P≤0.05). Compared with the model group, the high dose and high dose groups , Serum triglyceride content in aspirin group was significantly lower (P≤0.05). The levels of high-density lipoprotein in each dose group of Yinhuang capsule and aspirin group were significantly increased (P≤0.05). Conclusion: Yinjiao capsule can effectively improve myocardial ischemia, and can regulate blood lipids, thus protecting the myocardium.