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目的:研制雷公藤多苷纳米乳并对其理化性能、稳定性等进行评价。方法:结合雷公藤多苷在不同的油和表面活性剂中的溶解度以及伪三元相图的绘制,研制雷公藤多苷纳米乳,并对其类型、形态、粒径、理化参数及稳定性进行考察。结果:雷公藤多苷在聚氧乙烯氢化蓖麻油(RH-40)和肉豆蔻酸异丙酯(IPM)中溶解度较大,且以RH-40为表面活性剂,IPM为油相时纳米乳形成区域最大,最终纳米乳配方确定为RH-40∶IPM∶水,重量比为27∶3.3∶69.7,其中可添加浓度小于5%的透皮促渗剂氮酮;制备的雷公藤多苷纳米乳为棕黄色,澄清透明,流动性良好的O/W型纳米乳,该纳米乳粒子形态主要为圆球形,平均粒径为23.6nm,稳定性良好。结论:研制的雷公藤多苷纳米乳是质量稳定的新制剂。
OBJECTIVE: To develop TWH nanoemulsion and evaluate its physicochemical properties, stability and so on. Methods: According to the solubility of tripterygium wilfordii glycosides in different oils and surfactants and the pseudo-ternary phase diagram, we studied the type, morphology, particle size, physico-chemical parameters and stability To inspect. Results: Tripterygium glycosides were more soluble in polyoxyethylene hydrogenated castor oil (RH-40) and isopropyl myristate (IPM), with RH-40 as surfactant and IPM as oil phase. The formation area of the largest, final nanoemulsion formula is determined RH-40: IPM: water, the weight ratio of 27: 3.3: 69.7, which can be added at a concentration of less than 5% penetration enhancer Azone; Milk is yellow-brown, clear and transparent, good fluidity O / W type nanoemulsion, the shape of the nanoemulsion is mainly spherical, the average particle size of 23.6nm, good stability. Conclusion: The triptolide glycoside nanoemulsion is a new stable preparation.