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目的比较盐酸关附甲素(AHH)与普罗帕酮注射液终止阵发性室上性心动过速(PSVT)的疗效及不良事件发生率。方法随机双盲对照试验。入选自发或经食管调搏心房诱发的PSVT 患者,采用1:1随机静脉注射观察药 AHH 或对照药普罗帕酮;AHH 剂量为4 mg/kg,普罗帕酮为1 mg/kg。若转复为窦性心律,随时终止注射,无效则补充第二剂。记录是否转复以及转复前后参数。结果入选 AHH 组101例,普罗帕酮组100例。用药前两组间患者人口统计学资料及基线特征相似。AHH 组在40min 内转复为窦性心律的患者为72例(71.3%),普罗帕酮组为73例(73.0%),P=0.6368。AHH 组平均转复时间为(9.62±8.39)min,普罗帕酮组为(10.61±9.47)min,P=0.5035。转复后各参数如自然窦房结恢复时间等两组差异无统计学意义。AHH 组出现不良事件的患者为11例(10.9%),普罗帕酮组为18例(18.0%),P=0.1653。AHH 组最常见的不良事件为口唇、舌、手发麻。结论在研究所采用的剂量下,AHH 终止 PSVT 安全有效,其疗效和不良事件的发生率与普罗帕酮相当。
Objective To compare the efficacy and adverse events of paroxysmal supraventricular tachycardia (PSVT) with guanosine monophosphate (AHH) and propafenone injection. Methods Randomized double-blind controlled trial. Patients with PSVT who were induced by spontaneous or transesophageal atrial pacing were randomized to 1: 1 intravenous injection of prophylactone AHH or control propafenone; AHH at 4 mg / kg and propafenone at 1 mg / kg. If converted to sinus rhythm, at any time to terminate the injection, the second supplement is invalid. Record whether the recovery and recovery before and after the parameters. Results 101 cases were selected AHH group and 100 cases propafenone group. The demographic data and baseline characteristics were similar between the two groups before treatment. In AHH group, 72 (71.3%) patients were converted to sinus rhythm in 40 minutes, 73 (73.0%) in propafenone group, P = 0.6368. The mean recovery time was (9.62 ± 8.39) min in AHH group and (10.61 ± 9.47) min in propafenone group, P = 0.5035. After the conversion of parameters such as natural sinus node recovery time was no significant difference between the two groups. Eleven patients (10.9%) had adverse events in AHH group and 18 patients (18.0%) in propafenone group, P = 0.1653. The most common adverse events in the AHH group were lips, tongue and hand numbness. Conclusions AHH termination of PSVT is safe and effective at the dose used in the study, with comparable efficacy and adverse events as propafenone.