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目的 探讨风湿性心脏病患者白细胞介素-2和白细胞介素-6的血浆变化与风湿活动的关系。方法 随机选择25例风心病风湿活动患者及30例非风湿活动患者,用放射免疫竟争结合法检测其血浆IL-2和IL-6水平。结果 风心病人风湿活动期血浆IL-6升高,IL-2降低,风心病非风湿活动患者血浆IL-6轻度升高,而IL-2无变化。结论 轻度IL-6升高的非风湿活动患存在隐匿风湿活动,需辅以抗风湿治疗。
Objective To investigate the relationship between plasma changes of interleukin-2 and interleukin-6 in patients with rheumatic heart disease and rheumatic activity. Methods Twenty-five patients with rheumatic rheumatic disease and 30 non-rheumatic active patients were randomly selected. Plasma IL-2 and IL-6 levels were measured by radioimmunoassay. Results The rheumatic activity of rheumatoid patients with elevated plasma IL-6, IL-2 decreased, rheumatic heart disease patients with non-rheumatoid activity of plasma IL-6 slightly increased, while no change in IL-2. Conclusions There is occult rheumatic activity in non-rheumatoid activity with mild IL-6 elevation, which should be supplemented with antirheumatic therapy.