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为了解含银6%(g/g)的无机银抗菌剂的抗菌与破坏HBsAg效果及毒性,进行了纸片抑菌环测定、载体定性HBsAg试验与毒性试验。结果,该抗菌剂加水稀释20、200、400倍的混悬液所染滤纸,分别对白色念珠菌、金黄色葡萄球菌、大肠杆菌有抑菌效果;含该剂0.5%(g/g)的塑料洗衣球对大肠杆菌作用 5min,有抑菌作用;以该剂10倍稀释的悬液作用24h,才可破坏不锈钢片表面HBsAg抗原性。该抗菌剂对雌、雄小鼠经口LD50>5000mg/kg,对兔皮肤一次性刺激积分为0,微核试验阴性。
In order to understand the antibacterial and destructive HBsAg effect and toxicity of 6% (g / g) silver inorganic antibacterial agent, the bacteriostatic ring determination, carrier qualitative HBsAg test and toxicity test were carried out. As a result, the antibacterial agent was diluted 20,200,400 times by dilution with water to filter paper, which has antibacterial activity against Candida albicans, Staphylococcus aureus and Escherichia coli respectively. The antibacterial agent containing 0.5% (g / g ) Of the plastic laundry ball on E. coli 5min, antibacterial effect; to the agent 10-fold diluted suspension for 24h, can destroy the surface of stainless steel HBsAg antigen. The antibacterial agent in female and male mice oral LD50> 5000mg / kg, a one-time stimulation of rabbit skin irritation score of 0, the micronucleus test was negative.