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血小板的过度活化与凝血,动脉粥样硬化过敏性休克等多种病理改变有关。在促进血小板活化的诸因素中,近年发现的血小板活化因子(Platelet-Activating Factor,PAF)是作用最强者。PAF是多种细胞在适宜刺激下释放的一种磷脂介质,该介质在很低的浓度下即可引起血小板变形,聚集和释放反应。因而,寻找特异的PAF拮抗剂有可能对上述有关疾病的治疗提供适宜的药物。为此,我们以PAF引起的兔血小板聚集为指标检查了从近百种中草药
Platelet over-activation and coagulation, atherosclerotic anaphylactic shock and other pathological changes. Among the factors that promote platelet activation, Platelet-Activating Factor (PAF) has been found to be the strongest in recent years. PAF is a phospholipid mediator that is released by a variety of cells under appropriate stimuli. At very low concentrations, PAF can cause platelet deforming, aggregation and release reactions. Therefore, the search for specific PAF antagonists may provide the appropriate drugs for the treatment of these diseases. To this end, we PAF induced rabbit platelet aggregation as an indicator to check from nearly a hundred kinds of Chinese herbal medicine