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应用BSA免疫组织化学方法检测 2 0例囊腺瘤、6例交界性囊腺瘤 ,34例囊腺癌的nm2 3、C erbB 2蛋白的表达。结果 :在良性、交界性囊腺瘤及囊腺癌中nm2 3的阳性表达分别为 10 0 %、10 0 %、88% ;C erbB 2的表达率分别为0 %、16 6 %、47 3%。nm2 3的表达率随肿瘤分化成熟度降低及临床分期增高而降低 ,C erbB 2与nm2 3表达率呈负相关。表明nm2 3蛋白失活或减少 ,C erbB 2蛋白的过表达与卵巢上皮来源的肿瘤发生、演进有关。
BSA immunohistochemistry was used to detect the expression of nm23, C erbB 2 in 20 cases of cystadenoma, 6 cases of borderline cystadenoma and 34 cases of cystadenocarcinoma. Results: The positive expression of nm23 in benign, borderline cystadenoma and cystadenocarcinoma was 100%, 100%, 88% respectively; the expression rates of C erbB 2 were 0%, 16 6%, 47 3 %. The expression of nm23 decreased with the progress of tumor differentiation and maturation and the clinical stage. The expression of C erbB 2 was negatively correlated with the expression of nm23. Indicating that nm23 protein inactivation or decrease, C erbB2 protein overexpression and ovarian epithelial origin of the tumor, the evolution of.