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目的探讨吡格列酮(PGT)对早期糖尿病肾病(DN)患者血清炎症因子的影响。方法 60例早期DN患者随机分为两组:对照组用常规西药治疗;治疗组在此基础上加用PGT。疗程均为3个月。用ELISA测定治疗前后血清高敏C反应蛋白(hs-CRP)、白细胞介素6(IL-6)表达水平。结果与治疗前比较,两组治疗后血清hs-CRP、IL-6水平均下降(P<0.05),治疗组与对照组治疗后同期比较,下降更为明显(P<0.01)。结论 PGT可通过降低早期DN患者血清hs-CRP、IL-6的表达,抑制炎症反应,起到对DN的保护作用。
Objective To investigate the effect of pioglitazone (PGT) on serum inflammatory factors in patients with early diabetic nephropathy (DN). Methods Sixty patients with early DN were randomly divided into two groups: the control group was treated with conventional western medicine; and the treatment group was treated with PGT. Treatment are 3 months. Serum high-sensitivity C-reactive protein (hs-CRP) and interleukin-6 (IL-6) levels were measured by ELISA before and after treatment. Results Compared with those before treatment, the levels of hs-CRP and IL-6 in both groups decreased after treatment (P <0.05), and decreased more significantly in treatment group and control group after treatment (P <0.01). Conclusion PGT can protect DN by decreasing the expression of hs-CRP and IL-6 in sera of patients with early DN and inhibiting the inflammatory reaction.