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目的 :了解HLA -DQB1与广州地区HBV感染的关系。方法 :PCR -SSO基因分型技术 ,对南方人群中 6 3个不相关的正常个体和 6 3个不相关HBV感染患者 (HbsAg、HBeAg、HbcAb检测阳性 )HLA -DQB1位点进行了基因分型调查。结果 :两者的HLA -DQB1的各等位基因表现型频率无显著差异。结论 :南方人群HBV感染与HLA-DQB1无显著相关性。
Objective: To understand the relationship between HLA-DQB1 and HBV infection in Guangzhou. Methods: PCR-SSO genotyping was used to genotype HLA-DQB1 loci in 63 unrelated normal individuals and 63 unrelated HBV infected patients in southern China (positive for HBsAg, HBeAg and HbcAb) survey. Results: There was no significant difference in allele frequencies of HLA-DQB1 between the two groups. Conclusion: There is no significant correlation between HBV infection and HLA-DQB1 in southern population.