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目的:探讨复方小叶女贞茶(又称“清醇绿宝茶”)调节大鼠血脂和影响动物体重机理,为研制防治酒精性肝病,降脂保肝新产品提供理论依据。方法:采用大鼠高血脂动物模型4组,以不同剂量复方小叶女贞茶浓缩液分别灌胃受试动物32天,测量各组动物体重、血清总胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白胆固醇(HDL-C)。结果:经口给予大鼠不同剂量的复方小叶女贞茶1.2、2.4、7.2g/kg体重剂量组均能明显降低大鼠血清TC、TG水平,与对照组相比,有显著性差异(P<0.05);1.2、2.4g/kg体重剂量组能极明显升高大鼠HDL-C水平,与对照组相比,有显著性差异(P<0.01,P<0.05)。结论:研究提示复方小叶女贞茶对大鼠高血脂动物有一定的辅助调节血脂作用。
Objective: To investigate the regulation mechanism of Compound Ligustrum lucidum tea (also known as “Clean alcohol Lvbao tea”) and the mechanism of animal weight, to provide a theoretical basis for the development of new products to prevent and treat alcoholic liver disease, lipid-lowering and liver protection. METHODS: Four groups of rats with high-fatemia animal model were used. The animals were given intragastric administration of different concentrations of compound lobular liquefaction tea concentrate for 32 days. Body weight, serum total cholesterol (TC), and triglyceride (TG) were measured in each group. High-density lipoprotein cholesterol (HDL-C). RESULTS: After oral administration of different doses of Ligustrum lucidum tea, the doses of 1.2, 2.4, and 7.2 g/kg body weight of rats could significantly reduce the levels of serum TC and TG in rats, and there was a significant difference compared with the control group (P <0.05); 1.2,2.4 g/kg body weight dose group can significantly increase the level of HDL-C in rats, compared with the control group, there is a significant difference (P <0.01, P <0.05). Conclusion: The study suggests that compound leaves of Ligustrum lucidum tea has a certain role in the regulation of blood lipids in rats with hyperlipidemia.