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目的 :探讨细胞内细胞因子类型与狼疮性肾炎的发病关系。方法 :利用流式细胞分析法对狼疮性肾炎患者活动期 1 3例 ,非活动期 2 1例和健康志愿者 1 5例外周血中淋巴细胞内的细胞因子 ( IFN-γ、IL - 2、TNF-α和 IL - 4)和表面抗原 ( CD4 )进行分析。结果 :狼疮性肾炎患者 4种细胞内细胞因子分泌情况与健康志愿者相比无显著性差异 ,但 IFN-γ和 IL - 2在活动期与非活动期狼疮性肾炎组患者中相比较有明显统计学意义 ,且在活动期、非活动期狼疮性肾炎组患者与健康志愿者相比有显著性差异。结论 :狼疮性肾炎有强的 Th1优势。
Objective: To investigate the relationship between intracellular cytokine types and the pathogenesis of lupus nephritis. Methods: The levels of cytokines (IFN - γ, IL - 2, IL - 1β, IL - 1β, IL - 1β) in peripheral blood lymphocytes of 15 patients with lupus nephritis, 21 inactive patients and 15 healthy volunteers were detected by flow cytometry. TNF-α and IL-4) and surface antigen (CD4). Results: There was no significant difference in cytokines secretion among 4 kinds of intracellular cytokines in patients with lupus nephritis compared with healthy volunteers, but the levels of IFN-γ and IL-2 in active and inactive lupus nephritis patients were significantly higher than those in healthy volunteers Statistical significance, and in active, inactive lupus nephritis patients compared with healthy volunteers were significantly different. Conclusion: Lupus nephritis has a strong Th1 advantage.