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在哺乳动物与人类的皮肤、呼吸道、肝脏及小肠的微粒体中有能代谢活化或解毒多种药物与致癌剂的酶系。细胞色素P-450和芳烃羟化酶即是参与致癌剂——苯并芘及其它多环芳烃代谢活化的微粒体酶系,能被某些膳食因素及致癌剂所调节。实验研究与人类流行病学调查证明维生素A具有抗癌作用,但是对其抗癌机理仍不清楚。据推测,β-胡萝卜素(BC)可能具有较维生素A更强的抗癌活性。本研究旨在通过致癌剂代谢酶活性测定,了解维生素A的一种可能的抗癌机理,并比较活性维生素A(醋酸视黄醇酯)与BC对芳烃羟化酶(AHH)活性的影响。
In mammals and human skin, respiratory tract, liver and small intestine in the body can metabolically activate or detoxify a variety of drugs and carcinogens enzyme system. Cytochrome P-450 and aromatase hydroxylase are involved in the carcinogen - benzopyrene and other PAH metabolic activation of microsomal enzymes, can be some dietary factors and carcinogens regulate. Experimental studies and human epidemiological studies have shown that vitamin A has anti-cancer effects, but its anticancer mechanism remains unclear. It is speculated that β-carotene (BC) may have stronger anti-cancer activity than vitamin A. The aim of this study was to investigate a possible anti-cancer mechanism of vitamin A by measuring the activity of carcinogen metabolic enzymes and to compare the effects of active vitamin A (retinol acetate) and BC on aromatase hydroxylase (AHH) activity.