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目的：探讨老化过程中 Ｔ 淋巴细胞功能的变化规律。方法：以 ６２０ 例不同年龄的在职与离退休男性职工为研究对象，应用生物测定法检测了外周血 Ｔ 淋巴细胞丝裂原反应性、血浆 Ｉ Ｌ２ 活性和 ｓ Ｉ Ｌ２ Ｒ 的表达。结果：①外周血 Ｔ 淋巴细胞丝裂原反应性随增龄而下降，与年龄呈明显负相关关系（ｒ＝ － ０５９５ ４， Ｐ＜ ００００ １）；②血浆 Ｉ Ｌ２ 活性也随增龄而下降，与年龄也呈明显的负相关关系（ｒ＝ － ０３５２ ２， Ｐ＜ ００００ １）；③５０ 岁以上年龄组 ｓ Ｉ Ｌ２ Ｒ 表达水平随增龄有增高趋势，５０～５９岁组ｓ Ｉ Ｌ２ Ｒ 表达水平增高最明显。④相关检验表明，外周血 Ｔ 淋巴细胞丝裂原反应性与血浆 Ｉ Ｌ２活性呈明显的正相关关系。结论：老龄人群 Ｔ 淋巴细胞转化和分泌功能均明显下降。
Objective: To investigate the changes of T lymphocyte function during aging. Methods: 620 working and retired male employees of different ages were selected as the research objects. The bioactivity of mitochondria, T lymphocyte activity and IL-2R in peripheral blood were detected by bioassay . Results: (1) The mitogenic reactivity of peripheral blood T lymphocytes decreased with increasing age, but negatively correlated with age (r = - 0595 4, P <0000 1). ② Plasma I L2 activity (R = - 0352 2, P <0000 1). ③The expression level of s I L2 R in the age group of 50 years old increased with the increase of age Increasing trend, 50 ~ 59-year-old group s I L 2 R expression increased most significantly. ④ The correlation test showed that peripheral blood T lymphocytes mitogen reactivity and plasma I L 2 activity was significantly positive correlation. CONCLUSION: The transformation and secretion of T lymphocytes in aging population are obviously decreased.