本文总结了前列腺癌首次治疗失败后的临床处理经验。对85例临床资料齐全的病例分析、观察其恶化的临床表现、治疗方法及其疗效。结果16例病情稳定,占18.8％;69例出现局部复发或远处转移症状,占81.2％。主要恶化症状为骨痛、尿潴留、肾积水、血尿和脊髓压迫等、内分泌治疗和放疗仍是目前主要的治疗手段,内分泌治疗宜早不宜迟,间断性雄激素阻断治疗应予提倡,放疗对骨痛的缓解有一定价值。 This article summarizes the experience of clinical management following the failure of the first treatment of prostate cancer. 85 cases of clinical data complete case analysis to observe the clinical manifestations of deterioration, treatment and efficacy. Results 16 cases were stable, accounting for 18.8%; 69 cases showed local recurrence or distant metastasis, accounting for 81.2%. The main symptoms of deterioration of pain, urinary retention, hydronephrosis, hematuria and spinal cord compression, endocrine therapy and radiotherapy is still the main treatment, endocrine therapy sooner rather than later, intermittent androgen blockade therapy should be advocated, Radiation on bone pain relief has a certain value.