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为了研究丙型肝炎的HLA-Ⅱ类抗原相关性免疫发病机制,对47例慢性病毒性肝炎患者的肝活检组织标本应用免疫组织化学技术研究了肝内HLA-Ⅱ类抗原和HCV,NS3抗原的表达。11例慢性丙型肝炎患者中3例肝内HLA-Ⅱ类抗原表达呈阳性,其阳性程度明显低于慢性乙型肝炎患者(15/19)和慢性乙型和丙型肝炎病毒重叠感染者(15/17)。10例患者肝细胞内HCV,NS3抗原阳性,其中6例为慢性丙型肝炎患者,4例为慢性乙型和丙型肝炎病毒重叠感染者。慢性乙型肝炎患者的肝细胞中无HCV,NS3抗原阳性。尽管在HCV,NS3抗原阳性肝细胞表面未发现HLA-Ⅱ类抗原,但HLA-Ⅱ类抗原阳性表达明显与肝组织损伤的严重性有关。因此肝内HLA-Ⅱ类抗原的表达可能在慢性丙型肝炎患者的免疫发病中有一定的作用
In order to study the pathogenesis of HLA-Ⅱantigen-associated immunity in hepatitis C, the expression of HLA-Ⅱand HCV, NS3 antigen in liver tissues of 47 patients with chronic viral hepatitis were studied by immunohistochemistry . Of the 11 chronic hepatitis C patients, 3 showed positive expression of HLA-Ⅱ antigen in the liver and their positive rates were significantly lower than those of patients with chronic hepatitis B (15/19) and those with chronic hepatitis B and C ( 15/17). Among 10 patients, HCV and NS3 were positive in hepatocytes, of which 6 were chronic hepatitis C patients and 4 were chronic hepatitis B and C virus infections. Chronic hepatitis B patients without HCV, NS3 antigen positive. Although no HLA-class II antigens were found on the surface of HCV and NS3-positive hepatocytes, the positive expression of HLA-class II antigens was significantly associated with the severity of liver injury. Therefore, the expression of HLA class II antigens in the liver may play a role in the immune pathogenesis of chronic hepatitis C patients