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目的探讨联合检测氨基末端脑钠肽前体和高敏C反应蛋白(hsCRP)在急性冠状动脉综合征中的临床价值。方法将急性冠状动脉综合征(ACS)患者106例,分为不稳定型心绞痛组(UAP组)36例,急性非ST段抬高性心肌梗死组(NSTEMI组)37例与急性ST段抬高性心肌梗死组(STEMI组)33例;同期正常体检者30例作为对照组,分别检测血清氨基末端脑钠肽前体和高敏C反应蛋白水平,并进行比较。结果 ACS组血清氨基末端脑钠肽前体与高敏C反应蛋白水平显著高于对照组(P<0.05);NSTEMI组氨基末端脑钠肽前体水平高于UAP组(P<0.05);STEMI组氨基末端脑钠肽前体、高敏C反应蛋白水平高于NSTEMI组和UAP组(P<0.05);NSTEMI组与UAP组高敏C反应蛋白水平比较差异有统计学意义(P>0.05)。结论联合检测氨基末端脑钠肽前体和高敏C反应蛋白水平可判断急性冠状动脉综合征的严重程度,对其诊治及预后评价均有重要参考价值。
Objective To investigate the clinical value of combined detection of N-terminal pro-brain natriuretic peptide and high-sensitivity C-reactive protein (hsCRP) in acute coronary syndrome. Methods A total of 106 patients with acute coronary syndrome (ACS) were divided into unstable angina (UAP) group (n = 36) and acute ST-segment elevation myocardial infarction group (nSTEMI) Thirty patients with STEMI (STEMI group) and 30 normal subjects at the same period were taken as control group. Serum amino-terminal pro-brain natriuretic peptide and high-sensitivity C-reactive protein were detected and compared. Results The levels of serum amino-terminal pro-brain natriuretic peptide and high-sensitivity C-reactive protein in ACS group were significantly higher than those in control group (P <0.05). The levels of N-terminal pro brain natriuretic peptide in NSTEMI group were higher than those in UAP group N-terminal pro-brain natriuretic peptide precursor and high-sensitivity C-reactive protein were higher in NSTEMI group and UAP group (P <0.05). There was significant difference in high sensitivity C-reactive protein between NSTEMI group and UAP group (P> 0.05). Conclusions The combined detection of N-terminal pro-brain natriuretic peptide and high-sensitivity C-reactive protein can judge the severity of acute coronary syndrome, which has important reference value for diagnosis and prognosis evaluation.