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目的:探讨宫内暴露高糖环境与3岁龄儿童肥胖程度和血压的相关性。方法:回顾性研究156例妊娠期糖尿病(GDM)患者的孕期情况及其子代3岁时三角肌皮肤厚度与肩胛下肌皮肤厚度的总和、体质指数及血压;同时对同期分娩的209例正常孕妇及其子代检测以上指标,作为对照组。对所得数据进行统计学分析。结果:受教育程度及家庭收入较高的孕妇患GDM的风险较低。GDM孕妇子代的皮肤厚度为(8.2±1.5)cm,显著高于非GDM孕妇子代的皮肤厚度〔(4.8±1.3)cm〕(P=0.025)。孕期血糖控制不佳的孕妇其子代的体质指数和皮肤厚度显著增高。结论:宫内暴露高糖环境可增加儿童期肥胖的风险,而孕期严格控制血糖可能改善儿童的不良结局。
Objective: To investigate the correlation between intrauterine exposure to high glucose and obesity and blood pressure in 3-year-old children. Methods: A retrospective study of 156 cases of gestational diabetes mellitus (GDM) during pregnancy and its offspring 3 years old when the sum of the thickness of the deltoid muscle and the subscapular skin thickness, body mass index and blood pressure; simultaneous delivery of 209 cases of normal Pregnant women and their offspring to detect the above indicators, as a control group. The data obtained for statistical analysis. Results: Pregnant women with higher levels of education and higher family income had a lower risk of developing GDM. Skin thickness of GDM pregnant women was (8.2 ± 1.5) cm, significantly higher than that of non-GDM pregnant women [(4.8 ± 1.3) cm] (P = 0.025). Pregnant women with poor glycemic control had significantly higher BMI and skin thickness in their offspring. CONCLUSIONS: Intrauterine exposure to high glucose conditions increases the risk of childhood obesity, whereas strict control of blood glucose during pregnancy may improve adverse outcomes in children.