磺胺类药物应用于临床已将近三十年。磺胺类药物的问世,为抗感染治疗开辟了新的纪元。近年来虽然由于抗菌素的发现及应用取代了部份磺胺类药物的地位,但是由于磺胺类药物应用方便、价格低廉、毒性较低、过敏反应较少,尤其是自1956年以来合成了一些新型的作用持续时间较久的制剂,因此至今它仍不失为抗感染治疗中的重要武器之一。作用持久的磺胺类药物具有吸收良好而排泄较慢、因而血中有效浓度得以持续较久的特点。常用的制剂有磺胺甲氧嗪、磺胺双甲氧嘧啶(sulfadimethoxinum)等。现仅就磺胺甲氧 Sulfa drugs used in clinical practice for nearly three decades. The advent of sulfonamides has opened up a new era for anti-infective treatment. In recent years, due to the discovery and application of antibiotics to replace the status of some sulfa drugs, but due to sulfonamides convenient application, low price, low toxicity, less allergic reactions, especially since 1956 since the synthesis of some new It lasts longer and therefore remains one of the key weapons in anti-infective therapy. Long-lasting role of sulfa drugs with good absorption and excretion is slow, so the effective concentration of blood to last longer. Commonly used formulations are sulfamethoxazine, sulfadimethoxine (sulfadimethoxinum) and so on. Now only sulfamethoxazole