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目的探讨注射用血栓通对急性脑梗死患者炎症因子及预后的影响。方法 96例急性脑梗死患者随机分为治疗组和对照组各48例,对照组采用常规治疗,治疗组在此基础上加用注射用血栓通0.3 g加入生理盐水250 m L中静脉滴注,每日1次。两组均连续治疗14 d。结果治疗组总有效率91.67%,显著高于对照组的77.08%(P<0.05)。两组治疗后血清C反应蛋白(CRP)、白介素2(IL-2)、白介素6(IL-6)、肿瘤坏死因子α(TNF-α)及同型半胱氨酸(Hcy)水平均显著下降(P<0.01),且治疗组各指标均显著低于对照组(P<0.05或P<0.01)。随访3个月,治疗组NIHSS评分显著低于对照组(P<0.01),BI指数评分显著高于对照组(P<0.01),无残疾和轻、中度残疾患者的比例显著高于对照组(P<0.05或P<0.01),重度残疾患者比例显著低于对照组(P<0.05)。结论在常规治疗的基础上加用注射用血栓通可显著减轻急性脑梗死患者的炎症状态,降低Hcy水平,提高临床疗效,促进病情康复,改善预后。
Objective To investigate the effect of Xueshuantong Injection on inflammatory factors and prognosis in patients with acute cerebral infarction. Methods 96 patients with acute cerebral infarction were randomly divided into treatment group and control group of 48 cases, the control group with conventional treatment, the treatment group on this basis plus injection of thrombus through 0.3 g added 250 ml of normal saline intravenous infusion, 1 day. Both groups were treated for 14 days. Results The total effective rate in the treatment group was 91.67%, which was significantly higher than that in the control group (77.08%, P <0.05). Serum C-reactive protein (CRP), interleukin 2 (IL-2), interleukin 6 (IL-6), tumor necrosis factor alpha (TNF-alpha) and homocysteine (Hcy) (P <0.01), and the indexes in the treatment group were significantly lower than those in the control group (P <0.05 or P <0.01). After 3 months of follow-up, the NIHSS score of the treatment group was significantly lower than that of the control group (P <0.01), and the BI index score was significantly higher than that of the control group (P <0.01). The proportion of patients with no disability and mild to moderate disability was significantly higher than that of the control group (P <0.05 or P <0.01). The proportion of patients with severe disability was significantly lower than that of the control group (P <0.05). Conclusion Adding Xueshuantong Injection on the basis of routine treatment can significantly reduce the inflammatory state of patients with acute cerebral infarction, reduce the level of Hcy, improve the clinical curative effect, promote the recovery of the illness, and improve the prognosis.