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目的探讨食管癌每周7 d连续加速分割放疗的疗效和毒副反应。方法 60例食管癌患者随机分为2组,每周7 d连续加速分割组(加速组)及常规分割放疗组(常规组),每组各30例。加速组:每次分割剂量为2 Gy,每天1次,每周7 d,DT 56～66 Gy,共28～33次,照射时间28～33 d。常规组:每天1次,共5d,常规分割,DT 56～66 Gy,共28～33次,照射时间37～45 d。结果加速组的近期疗效较常规组好(P<0.05);2组1、3、5 a生存率比较差异均无统计学意义(P均>0.05)。结论连续加速分割放疗技术与常规放疗技术相比,可明显提高局部肿瘤控制效果。
Objective To investigate the curative effect and toxicity of continuous accelerated radiotherapy for 7 days per week in esophageal cancer. Methods Sixty patients with esophageal cancer were randomly divided into two groups. The rats were divided into two groups randomly. The rats in each group were treated with accelerated group (accelerated group) and conventional radiotherapy group (routine group) at 7 days per week. Accelerating group: Each dose divided into 2 Gy, once a day, 7 days a week, DT 56 ~ 66 Gy, a total of 28 to 33 times, irradiation time 28 ~ 33 d. Routine group: once a day, a total of 5d, conventional segmentation, DT 56 ~ 66 Gy, a total of 28 to 33 times, irradiation time 37 ~ 45d. Results The short-term curative effect of the accelerated group was better than that of the conventional group (P <0.05). There was no significant difference in the 1,3,5-year survival rates between the two groups (all P> 0.05). Conclusion Continuous accelerated radiotherapy and radiotherapy technology compared with conventional radiotherapy can significantly improve the effectiveness of local tumor control.