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自发性高血压和心肾缺血组织中钙离子水平明显升高。为探讨Ｎａ＋／Ｃａ２＋交换体在其中的作用，我们应用半定量逆转录一多聚酶链反应（ＲＴ一ＰＣＲ）技术，比较了自发性高血压大鼠（ＳＨＲ）部分组织、缺血时心肌和肾脏与其正常对照组织中Ｎａ＋／Ｃａ２＋交换体ｍＲＮＡ的水平。结果表明，ＳＨＲ所测组织中Ｎａ＋／Ｃａ２＋交换体ｍＲＮＡ较正常ＷＫＹ大鼠均降低。结扎４８小时引起的缺血肾脏Ｎａ＋／Ｃａ２＋交换体ｍＲＮＡ亦降低。而因异丙基肾上腺素引起的心肌缺血组织中，Ｎａ＋／Ｃａ２＋交换体基因的表达上升。
Ca2 + levels in spontaneously hypertensive and ischemic tissues were significantly higher. To explore the role of Na + / Ca2 + exchanger in this process, we used semi-quantitative reverse transcriptase-polymerase chain reaction (RT-PCR) to compare the expression of some tissues in spontaneously hypertensive rats (SHR) Na + / Ca2 + exchanger mRNA levels in normal control tissues. The results showed that the Na + / Ca2 + exchanger mRNA in SHR tissue was lower than that in normal WKY rats. 48 hours after ligation caused renal ischemic kidneys Na + / Ca2 + exchanger mRNA also decreased. However, the expression of Na + / Ca2 + exchanger gene was increased in isoproterenol induced myocardial ischemia.