AIM:Genetic polymorphism in enzymes of carcinogenmetabolism has been found to have the influence on thesusceptibility to cancer.Cytochrome P450 2E1(CYP2 E1)isconsidered to play an important role in the metabolicactivation of procarcinogens such as N-nitrosoamines andlow molecular weight organic compounds.The purpose ofthis study is to determine whether CYP450 2E1polymorphisms are associated with risks of gastric cancer.METHODS:We conducted a population based case-controlstudy in Changle county,Fujian Province,a high-riskregion of gastric cancer in China.Ninety-one incidentgastric cancer patients and ninety-four healthy controls wereincluded in our study.Datas including demographiccharacteristcs,diet intake,and alcohol and tobaccoconsumption of indivduais in our study were completad by astandardized questionnaire.PCR-RFLP revealed threegenotypes:heterozyote(C1/C2)and two homozygotes(C1/C1 and C2/C2)in CYP2E1.RESULTS:The frequency of variant genotypes(C1/C2 andC2/C2)in gastric cancer cases and controls was 36.3% and24.5%,respectively.The rare homozygous C2/C2 genotypewas found in 6 indivduals in gastric cancer group(6.6%),whereas there was only one in the control group(1.1%).However,there was no statistically significan differencebetween,the two groups(two-tailed Rsher’s exact test,P=0.066).Indlvduals in gastric cancer group were more likelyto carry genotype C1/C2(odds ratio,OR=1.50)and C2/C2(OR=7.34)than indlvduals in control group(x~2=4.597,fortrend P=0.032).The frequencies of genotypes with the C2allele(C1/C2 and C2/C2 genotypes)were compared withthose of genotypes without C2 alleie(C1/C1 genotype)among indlvduals in gastric cancer group and control groupaccording to the pattem of gastric cancer risk factors.Theresults show that indlvduals who exposed to these gastriccancer risk factors and carry the C2 allele seemed to have ahigher risk of developing gastric cancer.CONCLUSION:Polymorphism of CYP2E1 gene may havesome effct in the development of gastric cancer in Changle county,Fujian Province. AIM: Genetic polymorphism in enzymes of carcinogenmetabolism has been found to have the influence on the susceptibility to cancer.Cytochrome P450 2E1(CYP2 E1)isconsidered to play an important role in the metabolicactivation of procarcinogens such as N-nitrosoamines and low molecular weight organic compounds.The The purpose of this study is to determine whether CYP450 2E1 polymorphisms associated associated risks of gastric cancer.METHODS:We conducted a population based case-controlstudy in Changle county,Fujian Province,a high-riskregion of gastric cancer in China.Ninety-one incidentgastric cancer patients And ninety-four healthy controls were included in our study.Datas including demographiccharacteristcs,diet intake,and alcohol and tobaccoconsumption of indivduais in our study were completad by a standardizedized questionnaire.PCR-RFLP revealed threegenotypes:heterozyote(C1/C2)and two homozygotes(C1 /C1 and C2/C2)in CYP2E1.RESULTS:The frequency of variant genotypes(C1/C2 andC2/C2) in gastric cancer cas Es and controls was 36.3% and24.5%,respectively.The rare homozygous C2/C2 genotypewas found in 6 indivduals in gastric cancer group(6.6%),whereas there was only one in the control group(1.1%).However,there Was no ordly significan differencebetween, the two groups(two-tailed Rsher’s exact test,P=0.066).Indlvduals in gastric cancer group were more likely to carry genotype C1/C2(odds ratio,OR=1.50)and C2/C2(OR= 7.34) than indlvduals in control group(x~2=4.597,fortrend P=0.032).The frequencies of genotypes with the C2allele(C1/C2 and C2/C2 genotypes)were compared withthose of genotypes without C2 alleie(C1/C1 genotype )among indlvduals in gastric cancer group and control groupaccording to the pattem of gastric cancer risk factors.Theresults show that indlvduals who exposed to these gastriccancer risk factors and carry the C2 allele seemed to have ahigher risk of developing gastric cancer.CONCLUSION:Polymorphism of CYP2E1 Gene may havesome effct in the development of gastric cancer in CHangle county,Fujian Province.